Ethyl Cellulose (EC)
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Ethyl cellulose ( EC ) |
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Ethyl cellulose can't dissolve in water, but soluble in many organic solvents, so EC used in tablets, granules of its adhesive agent. It can increase the hardness of tablets to reduce friability tablets, it can be used as film-forming agent to improve the appearance of tablets, isolated taste, to avoid the failure of water-sensitive drugs to prevent the influx of metamorphic change agents, promoting the safe storage of tablets, also can be used as reinforcing material for sustained release tablets. |
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Items |
K grade |
N grade |
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Ethoxy ( WT% ) |
45.5 – 46.8 |
47.5 – 49.5 |
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Viscosity mpa.s 5% solu. 20 *c |
4, 5, 7, 10, 20, 50, 70, 100, 150, 200, 300 |
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Loss on drying ( % ) |
≤ 3.0 |
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Chloride ( % ) |
≤ 0.1 |
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Residue on ignition ( % ) |
≤ 0.4 |
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Heavy metals ppm |
≤ 20 |
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Arsenic ppm |
≤ 3 |
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EC can be dissolved in various organic solvents, such as ethanol, isopropyl alcohol, other alcohols, ketones, aromatic and so on. Common solvent (volume ratio): |
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1) Toluene:Ethanol = 4:1 |
Alcohols and aromatics in the viscosity of the mixture, going down with alcohol content higher, when alcohol accounts for 30-35%, the lowest viscosity of the composition. Dissolution method: the EC under the stirring slowly add the container filled with a solvent until complete wetting dissolved. |
